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February 24.2026
2 Minutes Read

Why Women’s Heart Disease Risk Rises at Lower Plaque Levels

Female doctor checks woman's heart health, highlighting women's heart disease risk.

Understanding Women's Unique Heart Attack Risks

Every year, heart disease claims the lives of more women than any other cause, yet alarming disparities exist in how their risks are assessed compared to men's. Recent research points to a critical gap in medical protocols that may put women at increased risk of major cardiac events, despite their typically lower plaque volumes.

Lower Thresholds Indicate Higher Risks for Women

A pivotal study published in the journal Circulation: Cardiovascular Imaging reveals that while women generally have less artery-clogging plaque, their risk of heart problems, including heart attacks, begins rising at a lower plaque burden than men. The study's findings indicate that for women, risk of serious cardiac events spikes at just 20% plaque burden, while for men, it starts at 28%.

Dissecting the Details: Study Insights

The PROMISE trial, which examined data from over 4,200 individuals suffering from chest pain or shortness of breath, underscores this gender disparity. The study noted that only about 55% of women exhibited plaque, significantly less than the 75% of men. However, the alarming insight was that major cardiac events occurred at similar rates among both genders despite women's smaller plaque volumes—2.3% of women faced serious complications in comparison to 3.4% of men.

Why This Matters: Advancing Women's Health Care

Heart attacks in women often present differently than in men, emphasizing the need for sex-specific assessment criteria in clinical settings. As women advocate for better healthcare tailored to their biological differences, it becomes imperative for healthcare providers to utilize risk calculators and screening guidelines that reflect gender disparities accurately.

Taking Charge of Your Heart Health

Knowing these critical statistics empowers women to ask informed questions during doctor visits. Inquire about CT angiography if you're at risk, bring up sex-specific benchmarks, and monitor essential health metrics like LDL and HDL cholesterol, blood pressure, and blood sugar. These proactive measures can help bridge the gap in heart health assessment.

A Call for Change in Women's Health Insights

Understanding that women may face heart disease risks at lower plaque levels than previously thought exemplifies the essential evolution in cardiovascular care. The conversations sparked by this research could lead to better screening practices and ultimately save lives. Advocate for your health with informed discussions during medical appointments, ensuring your heart is accurately assessed on its own terms.

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